2/20/2013· Medical - Medicine
Cardiovascular and Gastrointestinal Toxicity of Selective Cyclo-oxygenase-2 Inhibitors in Man
It is well established that the use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs) increases the vulnerability of the gastrointestinal (GI) mucosa for the development of peptic lesions and serious ulcer complications. In addition, selective and traditional NSAIDs have also been associated with increased frequency of cardiovascular toxicity, especially in susceptible patients.
